› 1kpa

X-ray diffraction
2Å resolution

PKCI-1-ZINC

Released:
DOI: 10.2210/pdb1kpa/pdb
PDB entry 1kpa coloured by chain, front view.
PDB entry 1kpa coloured by chain, side view.
PDB entry 1kpa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins.
Lima CD, Klein MG, Weinstein IB, Hendrickson WA
Proc Natl Acad Sci U S A 93 5357-62 (1996)
PMID: 8643579

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156024 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine 5'-monophosphoramidase HINT1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 13.72 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P49773 (Residues: 2-126; Coverage: 99%)
Gene names: HINT, HINT1, PKCI1, PRKCNH1
Sequence domains: HIT domain
Structure domains: HIT-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 46.11Å b: 77.29Å c: 81.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.261
Expression system: Komagataella pastoris

Quick links

Citations

13 review citations

Heterologous protein expression in the methylotrophic yeast Pichia pastoris.
Cereghino et al. (2000)
12 more

12 mentions without citation

Innovative Tools for Mechanobiology: Unraveling Outside-In and Inside-Out Mechanotransduction.
Mohammed et al. (2019)
11 more