› 1kqi

Solution NMR

NMR Solution Structure of the trans Pro30 Isomer of ACTX-Hi:OB4219

Released:
DOI: 10.2210/pdb1kqi/pdb
PDB entry 1kqi coloured by chain, ensemble of 20 models, front view.
PDB entry 1kqi coloured by chain, ensemble of 20 models, side view.
PDB entry 1kqi coloured by chain, ensemble of 20 models, top view.
Source organism: Hadronyche infensa
Primary publication:
Solution structures of the cis- and trans-Pro30 isomers of a novel 38-residue toxin from the venom of Hadronyche Infensa sp. that contains a cystine-knot motif within its four disulfide bonds.
Rosengren KJ, Wilson D, Daly NL, Alewood PF, Craik DJ
Biochemistry 41 3294-301 (2002)
PMID: 11876637

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157987 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
U2-hexatoxin-Hi1a Chain: A
Molecule details ›
Chain: A
Length: 38 amino acids
Theoretical weight: 4.23 KDa
Source organism: Hadronyche infensa
UniProt:
  • Canonical: P60272 (Residues: 46-83; Coverage: 63%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Torsion angle dynamics. Refinement and energy minimization in a water shell using Cartesian dynamics and powell minimization.

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Citations

3 review citations

Diversity of folds in animal toxins acting on ion channels.
Mouhat et al. (2004)
2 more