› 1ktj

X-ray diffraction
2.15Å resolution

X-ray Structure Of Der P 2, The Major House Dust Mite Allergen

Released:
DOI: 10.2210/pdb1ktj/pdb
PDB entry 1ktj coloured by chain, front view.
PDB entry 1ktj coloured by chain, side view.
PDB entry 1ktj coloured by chain, top view.
Source organism: Dermatophagoides pteronyssinus
Primary publication:
The crystal structure of a major dust mite allergen Der p 2, and its biological implications.
Derewenda U, Li J, Derewenda Z, Dauter Z, Mueller GA, Rule GS, Benjamin DC
J Mol Biol 318 189-97 (2002)
PMID: 12054778

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155911 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mite group 2 allergen Der p 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.12 KDa
Source organism: Dermatophagoides pteronyssinus
Expression system: Escherichia coli
UniProt:
  • Canonical: P49278 (Residues: 18-146; Coverage: 100%)
Gene name: DERP2
Sequence domains: ML domain
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B, EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P2221
Unit cell:
a: 71.692Å b: 108.747Å c: 91.971Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.27
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors.
Miyake K. (2007)
16 more

15 mentions without citation

Relevant B cell epitopes in allergic disease.
Pomés A. (2010)
14 more