› 1ktx

Solution NMR

KALIOTOXIN (1-37) SHOWS STRUCTURAL DIFFERENCES WITH RELATED POTASSIUM CHANNEL BLOCKERS

Released:
DOI: 10.2210/pdb1ktx/pdb
PDB entry 1ktx coloured by chain, ensemble of 11 models, front view.
PDB entry 1ktx coloured by chain, ensemble of 11 models, side view.
PDB entry 1ktx coloured by chain, ensemble of 11 models, top view.
Source organism: Androctonus mauritanicus mauritanicus
Primary publication:
Kaliotoxin (1-37) shows structural differences with related potassium channel blockers.
Fernández I, Romi R, Szendeffy S, Martin-Eauclaire MF, Rochat H, Van Rietschoten J, Pons M, Giralt E
Biochemistry 33 14256-63 (1994)
PMID: 7524673

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150266 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel toxin alpha-KTx 3.1 Chain: A
Molecule details ›
Chain: A
Length: 38 amino acids
Theoretical weight: 4.03 KDa
Source organism: Androctonus mauritanicus mauritanicus
Expression system: Not provided
UniProt:
  • Canonical: P24662 (Residues: 1-37; Coverage: 97%)
Sequence domains: Scorpion short toxin, BmKK2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

5 review citations

The charybdotoxin family of K+ channel-blocking peptides.
Miller C. (1995)
4 more

5 mentions without citation

Discovery of KV 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges.
Gubič et al. (2021)
4 more