› 1kuw

Solution NMR

High-Resolution Structure and Localization of Amylin Nucleation Site in Detergent Micelles

Released:
DOI: 10.2210/pdb1kuw/pdb
PDB entry 1kuw coloured by chain, ensemble of 39 models, front view.
PDB entry 1kuw coloured by chain, ensemble of 39 models, side view.
PDB entry 1kuw coloured by chain, ensemble of 39 models, top view.
Source organism: Homo sapiens
Primary publication:
Conformational preferences of the amylin nucleation site in SDS micelles: an NMR study.
Mascioni A, Porcelli F, Ilangovan U, Ramamoorthy A, Veglia G
Biopolymers 69 29-41 (2003)
PMID: 12717720

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145613 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Islet amyloid polypeptide Chain: A
Molecule details ›
Chain: A
Length: 10 amino acids
Theoretical weight: 1.01 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10997 (Residues: 53-62; Coverage: 15%)
Gene name: IAPP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

4 review citations

Membrane permeabilization by Islet Amyloid Polypeptide.
Engel MF. (2009)
3 more

5 mentions without citation

Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases.
Fantini et al. (2010)
4 more