› 1kv0

X-ray diffraction
1.4Å resolution

Cis/trans Isomerization of Non-prolyl Peptide Bond Observed in Crystal Structure of an Scorpion Toxin

Released:
DOI: 10.2210/pdb1kv0/pdb
PDB entry 1kv0 coloured by chain, front view.
PDB entry 1kv0 coloured by chain, side view.
PDB entry 1kv0 coloured by chain, top view.
Source organism: Mesobuthus martensii
Primary publication:
Structural mechanism governing cis and trans isomeric states and an intramolecular switch for cis/trans isomerization of a non-proline peptide bond observed in crystal structures of scorpion toxins.
Guan RJ, Xiang Y, He XL, Wang CG, Wang M, Zhang Y, Sundberg EJ, Wang DC
J Mol Biol 341 1189-204 (2004)
PMID: 15321715

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157927 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-like toxin BmK-M7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 66 amino acids
Theoretical weight: 7.25 KDa
Source organism: Mesobuthus martensii
UniProt:
  • Canonical: P59854 (Residues: 1-66; Coverage: 100%)
Sequence domains: Scorpion toxin-like domain
Structure domains: Knottin, scorpion toxin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-18B
Spacegroup: P3121
Unit cell:
a: 32.758Å b: 32.758Å c: 176.822Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.144 0.142 0.164

Quick links

Citations

3 review citations

Voltage-gated sodium channel modulation by scorpion alpha-toxins.
Bosmans et al. (2007)
2 more

3 mentions without citation

Modular organization of α-toxins from scorpion venom mirrors domain structure of their targets, sodium channels.
Chugunov et al. (2013)
2 more