› 1l1h

X-ray diffraction
1.75Å resolution

Crystal Structure of the Quadruplex DNA-Drug Complex

Released:
DOI: 10.2210/pdb1l1h/pdb
PDB entry 1l1h coloured by chain, front view.
PDB entry 1l1h coloured by chain, side view.
PDB entry 1l1h coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structure of a G-quadruplex-ligand complex.
Haider SM, Parkinson GN, Neidle S
J Mol Biol 326 117-25 (2003)
PMID: 12547195

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114103 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand PYN 1 x PYN
Ligand K 4 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 55.451Å b: 42.736Å c: 26.926Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.139 0.219
Expression system: Not provided

Quick links

Citations

23 review citations

A hitchhiker's guide to G-quadruplex ligands.
Monchaud et al. (2008)
22 more

15 mentions without citation

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
14 more