› 1l1v

Solution NMR

UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE

Released:
DOI: 10.2210/pdb1l1v/pdb
PDB entry 1l1v coloured by chain, ensemble of 6 models, front view.
PDB entry 1l1v coloured by chain, ensemble of 6 models, side view.
PDB entry 1l1v coloured by chain, ensemble of 6 models, top view.
Source organism: Streptomyces antibioticus
Primary publication:
Looped out and perpendicular: deformation of Watson-Crick base pair associated with actinomycin D binding.
Chou SH, Chin KH, Chen FM
Proc Natl Acad Sci U S A 99 6625-30 (2002)
PMID: 12011426

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-114106 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
ACTINOMYCIN D Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.26 KDa
Source organism: Streptomyces antibioticus
Expression system: Not provided
5'-D(*GP*TP*CP*AP*CP*CP*GP*AP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 9 nucleotides
Theoretical weight: 2.7 KDa
Source organism: Streptomyces antibioticus
Expression system: Not provided

Ligands and Environments

No bound ligands
3 modified residues:
Ligand DVA 2 x DVA
Ligand SAR 2 x SAR
Ligand MVA 2 x MVA

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY, SIMULATED ANNEALING, MOLECULAR DYNAMICS
Expression system: Not provided

Quick links

Citations

2 review citations

Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis.
Olano et al. (2009)
1 more

1 mention without citation

Looped out and perpendicular: deformation of Watson-Crick base pair associated with actinomycin D binding.
Chou et al. (2002)