Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Integrin alphav-beta3 complex and peptide (preferred)
PDBe Complex ID:
PDB-CPX-138436 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Integrin alpha-V
Molecule details ›
Chain: A
Length: 957 amino acids
Theoretical weight: 105.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 957 amino acids
Theoretical weight: 105.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P06756 (Residues: 31-987; Coverage: 94%)
Sequence domains:
- FG-GAP repeat
- Integrin alpha Ig-like domain 1
- Integrin alpha Ig-like domain 2
- Integrin alpha Ig-like domain 3
Integrin beta-3
Molecule details ›
Chain: B
Length: 692 amino acids
Theoretical weight: 76.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 692 amino acids
Theoretical weight: 76.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P05106 (Residues: 27-718; Coverage: 91%)
Sequence domains:
- Integrin plexin domain
- Integrin beta chain VWA domain
- Integrin beta epidermal growth factor like domain 1
- EGF-like domain
- Integrin beta tail domain
Ligands and Environments
Experiments and Validation Details
X-ray source:
APS BEAMLINE 19-ID
Spacegroup:
P3221
Expression system: Spodoptera frugiperda
