› 1la0

Solution NMR

Solution Structure of Calcium Saturated Cardiac Troponin C in the Troponin C-Troponin I Complex

Released:
DOI: 10.2210/pdb1la0/pdb
PDB entry 1la0 coloured by chain, front view.
PDB entry 1la0 coloured by chain, side view.
PDB entry 1la0 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Solution structure of calcium-saturated cardiac troponin C bound to cardiac troponin I.
Dvoretsky A, Abusamhadneh EM, Howarth JW, Rosevear PR
J Biol Chem 277 38565-70 (2002)
PMID: 12147696

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140775 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 18.45 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09860 (Residues: 1-161; Coverage: 100%)
Gene name: TNNC1
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Rigid body minimization
Expression system: Escherichia coli BL21(DE3)

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Citations

5 review citations

Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation.
Metzger et al. (2004)
4 more

1 mention without citation

Predicting the disruption by UO2(2+) of a protein-ligand interaction.
Pible et al. (2010)