› 1laq

Solution NMR

Solution Structure of the B-DNA Duplex CGCGGTXTCCGCG (X=PdG) Containing the 1,N2-propanodeoxyguanosine Adduct with the Deoxyribose at C20 Opposite PdG in the C2' Endo Conformation.

Released:
DOI: 10.2210/pdb1laq/pdb
PDB entry 1laq coloured by chain, front view.
PDB entry 1laq coloured by chain, side view.
PDB entry 1laq coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structure of an oligodeoxynucleotide containing a 1,N(2)-propanodeoxyguanosine adduct positioned in a palindrome derived from the Salmonella typhimurium hisD3052 gene: Hoogsteen pairing at pH 5.2.
Weisenseel JP, Reddy GR, Marnett LJ, Stone MP
Chem Res Toxicol 15 127-39 (2002)
PMID: 11849038

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114123 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*CP*GP*CP*GP*GP*TP*(P)P*TP*CP*CP*GP*CP*G)-3' Chain: A
Molecule details ›
Chain: A
Length: 13 nucleotides
Theoretical weight: 4.02 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*CP*GP*CP*GP*GP*AP*(DNR)P*AP*CP*CP*GP*CP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 13 nucleotides
Theoretical weight: 3.96 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
2 modified residues:
Ligand P 1 x P
Ligand DNR 1 x DNR

Experiments and Validation Details

Entry percentile scores
Refinement method: Molecular dynamics using a simulated annealing protocol.
Expression system: Not provided

Quick links

Citations

4 review citations

Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function.
Prakash et al. (2005)
3 more

2 mentions without citation

Mechanical design of translocating motor proteins.
Hwang et al. (2009)
1 more