› 1lbc

X-ray diffraction
1.8Å resolution

Crystal structure of GluR2 ligand binding core (S1S2J-N775S) in complex with cyclothiazide (CTZ) as well as glutamate at 1.8 A resolution

Released:
DOI: 10.2210/pdb1lbc/pdb
PDB entry 1lbc coloured by chain, front view.
PDB entry 1lbc coloured by chain, side view.
PDB entry 1lbc coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanism of glutamate receptor desensitization.
Sun Y, Olson R, Horning M, Armstrong N, Mayer M, Gouaux E
Nature 417 245-53 (2002)
PMID: 12015593

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 263 amino acids
Theoretical weight: 29.19 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand ZN 5 x ZN
Ligand GLU 3 x GLU
Ligand CYZ 3 x CYZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21212
Unit cell:
a: 114.859Å b: 162.571Å c: 47.198Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.243
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

87 review citations

AMPA receptor trafficking at excitatory synapses.
Bredt et al. (2003)
86 more

15 mentions without citation

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
14 more