› 1lbe

X-ray diffraction
2.4Å resolution

APLYSIA ADP RIBOSYL CYCLASE

Released:
DOI: 10.2210/pdb1lbe/pdb
PDB entry 1lbe coloured by chain, front view.
PDB entry 1lbe coloured by chain, side view.
PDB entry 1lbe coloured by chain, top view.
Source organism: Aplysia californica
Primary publication:
Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38.
Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD
Nat Struct Biol 3 957-64 (1996)
PMID: 8901875

Function and Biology Details

Reaction catalysed: 
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151371 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.58 KDa
Source organism: Aplysia californica
UniProt:
  • Canonical: P29241 (Residues: 25-282; Coverage: 100%)
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 70.2Å b: 72.3Å c: 125.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.299

Quick links

Citations

27 review citations

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.
Malavasi et al. (2008)
26 more

2 mentions without citation

Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38.
Graeff et al. (2009)
1 more