› 1ldd

X-ray diffraction
2Å resolution

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex

Released:
DOI: 10.2210/pdb1ldd/pdb
PDB entry 1ldd coloured by chain, front view.
PDB entry 1ldd coloured by chain, side view.
PDB entry 1ldd coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP
Nature 416 703-9 (2002)
PMID: 11961546

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171362 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anaphase-promoting complex subunit 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 74 amino acids
Theoretical weight: 8.57 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12440 (Residues: 773-846; Coverage: 9%)
Gene names: APC2, L3105, L3108, RSI1, YLR127C
Sequence domains: Anaphase promoting complex (APC) subunit 2
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 54.7Å b: 72.9Å c: 79.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.266
Expression system: Escherichia coli

Quick links

Citations

229 review citations

RING domain E3 ubiquitin ligases.
Deshaies et al. (2009)
228 more

3 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
2 more