› 1lec

X-ray diffraction
2Å resolution

STRUCTURES OF THE LECTIN IV OF GRIFFONIA SIMPLICIFOLIA AND ITS COMPLEX WITH THE LEWIS B HUMAN BLOOD GROUP DETERMINANT AT 2.0 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1lec/pdb
PDB entry 1lec coloured by chain, front view.
PDB entry 1lec coloured by chain, side view.
PDB entry 1lec coloured by chain, top view.
Source organism: Griffonia simplicifolia
Primary publication:
Structures of the lectin IV of Griffonia simplicifolia and its complex with the Lewis b human blood group determinant at 2.0 A resolution.
Delbaere LT, Vandonselaar M, Prasad L, Quail JW, Wilson KS, Dauter Z
J Mol Biol 230 950-65 (1993)
PMID: 8478943

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150161 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Lectin-4 Chain: A
Molecule details ›
Chain: A
Length: 243 amino acids
Theoretical weight: 26.82 KDa
Source organism: Griffonia simplicifolia
Expression system: Not provided
UniProt:
  • Canonical: P24146 (Residues: 1-243; Coverage: 100%)
Sequence domains: Legume lectin domain
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
3 bound ligands:
Ligand MN 1 x MN
Ligand CA 1 x CA
Ligand SO4 1 x SO4
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
Spacegroup: P42212
Unit cell:
a: 78.9Å b: 78.9Å c: 89.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 not available not available
Expression system: Not provided

Quick links

Citations

7 review citations

Lectins.
Vijayan et al. (1999)
6 more

2 mentions without citation

Structural analysis and unique molecular recognition properties of a Bauhinia forficata lectin that inhibits cancer cell growth.
Lubkowski et al. (2017)
1 more