› 1lfa

X-ray diffraction
1.8Å resolution

CD11A I-DOMAIN WITH BOUND MN++

Released:
DOI: 10.2210/pdb1lfa/pdb
PDB entry 1lfa coloured by chain, front view.
PDB entry 1lfa coloured by chain, side view.
PDB entry 1lfa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.
Qu A, Leahy DJ
Proc Natl Acad Sci U S A 92 10277-81 (1995)
PMID: 7479767

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149037 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-L Chains: A, B
Molecule details ›
Chains: A, B
Length: 187 amino acids
Theoretical weight: 21.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20701 (Residues: 150-336; Coverage: 16%)
Gene names: CD11A, ITGAL
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

2 bound ligands:
Ligand MN 2 x MN
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 131.13Å b: 45.45Å c: 66.13Å
α: 90° β: 99.8° γ: 90°
R-values:
R R work R free
0.19 0.19 0.251
Expression system: Escherichia coli

Quick links

Citations

36 review citations

Integrins: bidirectional, allosteric signaling machines.
Hynes RO. (2002)
35 more

19 mentions without citation

Yeast surface display for protein engineering and characterization.
Gai et al. (2007)
18 more