› 1lfo

X-ray diffraction
2.3Å resolution

LIVER FATTY ACID BINDING PROTEIN-OLEATE COMPLEX

Released:
DOI: 10.2210/pdb1lfo/pdb
PDB entry 1lfo coloured by chain, front view.
PDB entry 1lfo coloured by chain, side view.
PDB entry 1lfo coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The crystal structure of the liver fatty acid-binding protein. A complex with two bound oleates.
Thompson J, Winter N, Terwey D, Bratt J, Banaszak L
J Biol Chem 272 7140-50 (1997)
PMID: 9054409

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136050 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein, liver Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.33 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P02692 (Residues: 1-127; Coverage: 100%)
Gene name: Fabp1
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

3 bound ligands:
Ligand OLA 2 x OLA
Ligand BEO 1 x BEO
Ligand UNX 1 x UNX
1 modified residue:
Ligand SMC 1 x SMC

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P3221
Unit cell:
a: 83.89Å b: 83.89Å c: 44.65Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.202 0.262
Expression system: Escherichia coli

Quick links

Citations

25 review citations

The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism.
Chmurzyńska A. (2006)
24 more

18 mentions without citation

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets.
Furuhashi et al. (2008)
17 more