› 1lio

X-ray diffraction
2.5Å resolution

STRUCTURE OF APO T. GONDII ADENOSINE KINASE

Released:
DOI: 10.2210/pdb1lio/pdb
PDB entry 1lio coloured by chain, front view.
PDB entry 1lio coloured by chain, side view.
PDB entry 1lio coloured by chain, top view.
Source organism: Toxoplasma gondii
Primary publication:
Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
Schumacher MA, Scott DM, Mathews II, Ealick SE, Roos DS, Ullman B, Brennan RG
J Mol Biol 298 875-93 (2000)
PMID: 10801355

Function and Biology Details

Reaction catalysed: 
ATP + adenosine = ADP + AMP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine kinase Chain: A
Molecule details ›
Chain: A
Length: 363 amino acids
Theoretical weight: 38.36 KDa
Source organism: Toxoplasma gondii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9TVW2 (Residues: 1-363; Coverage: 100%)
Gene name: AK
Sequence domains: pfkB family carbohydrate kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 47.1Å b: 68Å c: 56.8Å
α: 90° β: 100.8° γ: 90°
R-values:
R R work R free
0.2 0.198 0.26
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Adenosine kinase: exploitation for therapeutic gain.
Boison D. (2013)
3 more

3 mentions without citation

ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation.
Wang et al. (2020)
2 more