› 1lki

X-ray diffraction
2Å resolution

THE CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTION OF LEUKEMIA INHIBITORY FACTOR: IMPLICATIONS FOR RECEPTOR BINDING

Released:
DOI: 10.2210/pdb1lki/pdb
PDB entry 1lki coloured by chain, front view.
PDB entry 1lki coloured by chain, side view.
PDB entry 1lki coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding.
Robinson RC, Grey LM, Staunton D, Vankelecom H, Vernallis AB, Moreau JF, Stuart DI, Heath JK, Jones EY
Cell 77 1101-16 (1994)
PMID: 8020098

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140546 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukemia inhibitory factor Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 19.89 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P09056 (Residues: 24-203; Coverage: 100%)
Gene name: Lif
Sequence domains: LIF / OSM family
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 31.1Å b: 56.2Å c: 95.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 not available
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.
Heinrich et al. (1998)
22 more

12 mentions without citation

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11.
Metcalfe et al. (2020)
11 more