› 1lm7

X-ray diffraction
3Å resolution

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure

Released:
DOI: 10.2210/pdb1lm7/pdb
PDB entry 1lm7 coloured by chain, front view.
PDB entry 1lm7 coloured by chain, side view.
PDB entry 1lm7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure.
Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI
Nat Struct Biol 9 612-20 (2002)
PMID: 12101406

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147539 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Desmoplakin Chains: A, B
Molecule details ›
Chains: A, B
Length: 248 amino acids
Theoretical weight: 27.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15924 (Residues: 2209-2456; Coverage: 9%)
Gene name: DSP
Sequence domains: Plectin repeat
Structure domains: Plakin repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 48.293Å b: 99.773Å c: 51.687Å
α: 90° β: 97.58° γ: 90°
R-values:
R R work R free
0.249 0.249 0.296
Expression system: Escherichia coli

Quick links

Citations

29 review citations

Intermediate filaments: molecular structure, assembly mechanism, and integration into functionally distinct intracellular Scaffolds.
Herrmann et al. (2004)
28 more

5 mentions without citation

Mechanistic basis of desmosome-targeted diseases.
Al-Jassar et al. (2013)
4 more