› 1lmk

X-ray diffraction
2.6Å resolution

THE STRUCTURE OF A BIVALENT DIABODY

Released:
DOI: 10.2210/pdb1lmk/pdb
PDB entry 1lmk coloured by chain, front view.
PDB entry 1lmk coloured by chain, side view.
PDB entry 1lmk coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of a diabody, a bivalent antibody fragment.
Perisic O, Webb PA, Holliger P, Winter G, Williams RL
Structure 2 1217-26 (1994)
PMID: 7704531

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213038 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ANTI-PHOSPHATIDYLINOSITOL SPECIFIC PHOSPHOLIPASE C DIABODY Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 238 amino acids
Theoretical weight: 26.08 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 72.14Å b: 80.71Å c: 88.01Å
α: 90° β: 99.81° γ: 90°
R-values:
R R work R free
0.2 0.2 not available
Expression system: Escherichia coli

Quick links

Citations

18 review citations

3D domain swapping: as domains continue to swap.
Liu et al. (2002)
17 more

12 mentions without citation

Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10.
Klein et al. (2009)
11 more