› 1lp3

X-ray diffraction
3Å resolution

The Atomic Structure of Adeno-Associated Virus (AAV-2), a Vector for Human Gene Therapy

Released:
DOI: 10.2210/pdb1lp3/pdb
PDB entry 1lp3 coloured by chain, front view.
PDB entry 1lp3 coloured by chain, side view.
PDB entry 1lp3 coloured by chain, top view.
Source organism: adeno-associated virus 2
Primary publication:
The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy.
Xie Q, Bu W, Bhatia S, Hare J, Somasundaram T, Azzi A, Chapman MS
Proc Natl Acad Sci U S A 99 10405-10 (2002)
PMID: 12136130

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136598 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 519 amino acids
Theoretical weight: 58.77 KDa
Source organism: adeno-associated virus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P03135 (Residues: 217-735; Coverage: 71%)
Gene name: VP1
Sequence domains: Parvovirus coat protein VP2
Structure domains: Parvovirus coat protein VP1/VP2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P1
Unit cell:
a: 249.69Å b: 249.69Å c: 644.76Å
α: 90° β: 101.16° γ: 120°
R-values:
R R work R free
0.339 0.338 0.342
Expression system: Homo sapiens

Quick links

Citations

93 review citations

Progress and problems with the use of viral vectors for gene therapy.
Thomas et al. (2003)
92 more

105 mentions without citation

Origins and evolution of viruses of eukaryotes: The ultimate modularity.
Koonin et al. (2015)
104 more