Function and Biology Details
Reaction catalysed:
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Rab protein geranylgeranyltransferase component A
- GDP dissociation inhibitor
- Protein prenyltransferase, alpha subunit
- PFTB repeat
- FAD/NAD(P)-binding domain superfamily
- Prenyltransferase subunit beta
- Geranylgeranyl transferase type-2 subunit beta
- Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
3 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153474 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Geranylgeranyl transferase type-2 subunit alpha
Molecule details ›
Chain: A
Length: 567 amino acids
Theoretical weight: 64.98 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 567 amino acids
Theoretical weight: 64.98 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q08602 (Residues: 1-567; Coverage: 100%)
Sequence domains:
- Protein prenyltransferase alpha subunit repeat
- Rab geranylgeranyl transferase alpha-subunit, insert domain
Geranylgeranyl transferase type-2 subunit beta
Molecule details ›
Chain: B
Length: 331 amino acids
Theoretical weight: 36.89 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains: Prenyltransferase and squalene oxidase repeat
Structure domains: Glycosyltransferase
Length: 331 amino acids
Theoretical weight: 36.89 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical: Q08603 (Residues: 1-331; Coverage: 100%)
Sequence domains: Prenyltransferase and squalene oxidase repeat
Structure domains: Glycosyltransferase
Rab proteins geranylgeranyltransferase component A 1
Molecule details ›
Chain: R
Length: 650 amino acids
Theoretical weight: 72.59 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: GDP dissociation inhibitor
Structure domains:
Length: 650 amino acids
Theoretical weight: 72.59 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P37727 (Residues: 1-650; Coverage: 100%)
Sequence domains: GDP dissociation inhibitor
Structure domains:
