› 1lu4

X-ray diffraction
1.12Å resolution

1.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SECRETED MYCOBACTERIUM TUBERCULOSIS DISULFIDE OXIDOREDUCTASE HOMOLOGOUS TO E. COLI DSBE: IMPLICATIONS FOR FUNCTIONS

Released:
DOI: 10.2210/pdb1lu4/pdb
PDB entry 1lu4 coloured by chain, front view.
PDB entry 1lu4 coloured by chain, side view.
PDB entry 1lu4 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis.
Goulding CW, Apostol MI, Gleiter S, Parseghian A, Bardwell J, Gennaro M, Eisenberg D
J Biol Chem 279 3516-24 (2004)
PMID: 14597624

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161463 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble secreted antigen MPT53 Chain: A
Molecule details ›
Chain: A
Length: 136 amino acids
Theoretical weight: 14.62 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WG65 (Residues: 38-173; Coverage: 100%)
Gene names: MTCY274.09c, Rv2878c, mpb53, mpt53
Sequence domains: AhpC/TSA family
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P43212
Unit cell:
a: 60.64Å b: 60.64Å c: 79.775Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.152 0.216
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Protein disulfide isomerase: the structure of oxidative folding.
Gruber et al. (2006)
14 more

10 mentions without citation

The TB Structural Genomics Consortium: a decade of progress.
Chim et al. (2011)
9 more