› 1lu5

X-ray diffraction
2.4Å resolution

2.4 Angstrom Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex

Released:
DOI: 10.2210/pdb1lu5/pdb
PDB entry 1lu5 coloured by chain, front view.
PDB entry 1lu5 coloured by chain, side view.
PDB entry 1lu5 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
2.4-A crystal structure of the asymmetric platinum complex [Pt(ammine)(cyclohexylamine)]2+ bound to a dodecamer DNA duplex.
Silverman AP, Bu W, Cohen SM, Lippard SJ
J Biol Chem 277 49743-9 (2002)
PMID: 12377787

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114148 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3' Chains: A, C
Molecule details ›
Chains: A, C
Length: 12 nucleotides
Theoretical weight: 3.57 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3' Chains: B, D
Molecule details ›
Chains: B, D
Length: 12 nucleotides
Theoretical weight: 3.76 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand LPT 2 x LPT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 31.644Å b: 35.638Å c: 46.556Å
α: 79.53° β: 83.02° γ: 81.36°
Expression system: Not provided

Quick links

Citations

5 review citations

The resurgence of platinum-based cancer chemotherapy.
Kelland L. (2007)
4 more

5 mentions without citation

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.
Johnstone et al. (2016)
4 more