› 1lv9

Solution NMR

CXCR3 Binding Chemokine IP-10/CXCL10

Released:
DOI: 10.2210/pdb1lv9/pdb
PDB entry 1lv9 coloured by chain, ensemble of 10 models, front view.
PDB entry 1lv9 coloured by chain, ensemble of 10 models, side view.
PDB entry 1lv9 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.
Booth V, Keizer DW, Kamphuis MB, Clark-Lewis I, Sykes BD
Biochemistry 41 10418-25 (2002)
PMID: 12173928

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-X-C motif chemokine 10 Chain: A
Molecule details ›
Chain: A
Length: 77 amino acids
Theoretical weight: 8.65 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02778 (Residues: 22-98; Coverage: 100%)
Gene names: CXCL10, INP10, SCYB10
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MLE 1 x MLE

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

12 review citations

Chemokine: receptor structure, interactions, and antagonism.
Allen et al. (2007)
11 more

12 mentions without citation

Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands.
Metzemaekers et al. (2017)
11 more