› 1lwi

X-ray diffraction
2.7Å resolution

3-ALPHA-HYDROXYSTEROID/DIHYDRODIOL DEHYDROGENASE FROM RATTUS NORVEGICUS

Released:
DOI: 10.2210/pdb1lwi/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 1lwi coloured by chain, front view.
PDB entry 1lwi coloured by chain, side view.
PDB entry 1lwi coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+.
Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M
Biochemistry 35 10702-11 (1996)
PMID: 8718859

Function and Biology Details

Reaction catalysed: 
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-alpha-hydroxysteroid dehydrogenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 322 amino acids
Theoretical weight: 37.08 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P23457 (Residues: 1-322; Coverage: 100%)
Gene name: Akr1c9
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments


Cofactor: Ligand NAP 2 x NAP
No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
Spacegroup: P21
Unit cell:
a: 46.9Å b: 139.1Å c: 53.3Å
α: 90° β: 113.5° γ: 90°
R-values:
R R work R free
0.234 0.234 0.294

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Citations

16 review citations

Comparative anatomy of the aldo-keto reductase superfamily.
Jez et al. (1997)
15 more