› 1m4k

X-ray diffraction
2.3Å resolution

Crystal structure of the human natural killer cell activator receptor KIR2DS2 (CD158j)

Released:
DOI: 10.2210/pdb1m4k/pdb
PDB entry 1m4k coloured by chain, front view.
PDB entry 1m4k coloured by chain, side view.
PDB entry 1m4k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j).
Saulquin X, Gastinel LN, Vivier E
J Exp Med 197 933-8 (2003)
PMID: 12668644

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155114 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Killer cell immunoglobulin-like receptor 2DS2 Chain: A
Molecule details ›
Chain: A
Length: 200 amino acids
Theoretical weight: 22.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43631 (Residues: 22-221; Coverage: 71%)
Gene names: CD158J, KIR2DS2, NKAT5
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3121
Unit cell:
a: 97.535Å b: 97.535Å c: 54.375Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.221 0.247
Expression system: Escherichia coli

Quick links

Citations

19 review citations

MHC class I molecules and KIRs in human history, health and survival.
Parham P. (2005)
18 more

9 mentions without citation

The structural basis of ligand recognition by natural killer cell receptors.
Joyce et al. (2011)
8 more