› 1mb6

Solution NMR

Three dimensional solution structure of huwentoxin-IV by 2D 1H-NMR

Released:
DOI: 10.2210/pdb1mb6/pdb
PDB entry 1mb6 coloured by chain, ensemble of 20 models, front view.
PDB entry 1mb6 coloured by chain, ensemble of 20 models, side view.
PDB entry 1mb6 coloured by chain, ensemble of 20 models, top view.
Source organism: Cyriopagopus schmidti
Primary publication:
Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena.
Peng K, Shu Q, Liu Z, Liang S
J Biol Chem 277 47564-71 (2002)
PMID: 12228241

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160683 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Huwentoxin-IV Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 4.12 KDa
Source organism: Cyriopagopus schmidti
UniProt:
  • Canonical: P83303 (Residues: 53-87; Coverage: 54%)
Sequence domains: Ion channel inhibitory toxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing

Quick links

Citations

26 review citations

The roles of sodium channels in nociception: Implications for mechanisms of pain.
Cummins et al. (2007)
25 more

15 mentions without citation

Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities.
Wu et al. (2019)
14 more