› 1mcn

X-ray diffraction
2.7Å resolution

PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS

Released:
DOI: 10.2210/pdb1mcn/pdb
PDB entry 1mcn coloured by chain, front view.
PDB entry 1mcn coloured by chain, side view.
PDB entry 1mcn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Principles and pitfalls in designing site-directed peptide ligands.
Edmundson AB, Harris DL, Fan ZC, Guddat LW, Schley BT, Hanson BL, Tribbick G, Geysen HM
Proteins 16 246-67 (1993)
PMID: 8346191

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211567 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN) Chains: A, B
Molecule details ›
Chains: A, B
Length: 216 amino acids
Theoretical weight: 22.82 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
PEPTIDE N-ACETYL-D-HIS-L-PRO-NH2 Chain: P
Molecule details ›
Chain: P
Length: 4 amino acids
Theoretical weight: 277 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand DHI 1 x DHI

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3121
Unit cell:
a: 72.3Å b: 72.3Å c: 185.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.183 not available
Expression system: Not provided

Quick links

Citations

6 review citations

Treatment of osteoarthritis with aspartame.
Edmundson et al. (1998)
5 more

2 mentions without citation

Length-independent structural similarities enrich the antibody CDR canonical class model.
Nowak et al. (2016)
1 more