› 1md6

X-ray diffraction
1.6Å resolution

High resolution crystal structure of murine IL-1F5 reveals unique loop conformation for specificity

Released:
DOI: 10.2210/pdb1md6/pdb
PDB entry 1md6 coloured by chain, front view.
PDB entry 1md6 coloured by chain, side view.
PDB entry 1md6 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity.
Dunn EF, Gay NJ, Bristow AF, Gearing DP, O'Neill LA, Pei XY
Biochemistry 42 10938-44 (2003)
PMID: 12974628

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193056 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-36 receptor antagonist protein Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 16.89 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9QYY1 (Residues: 3-156; Coverage: 99%)
Gene names: Fil1d, IL36RN, Il1f5, Il1h3, Il1hy1
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P3221
Unit cell:
a: 78.932Å b: 78.932Å c: 69.74Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.204 0.213
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

The IL-1 family: regulators of immunity.
Sims et al. (2010)
9 more

7 mentions without citation

Structural Basis of IL-1 Family Cytokine Signaling.
Fields et al. (2019)
6 more