› 1mdg

X-ray diffraction
1.5Å resolution

An Alternating Antiparallel Octaplex in an RNA Crystal Structure

Released:
DOI: 10.2210/pdb1mdg/pdb
PDB entry 1mdg coloured by chain, front view.
PDB entry 1mdg coloured by chain, side view.
PDB entry 1mdg coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
An eight-stranded helical fragment in RNA crystal structure: implications for tetraplex interaction.
Pan B, Xiong Y, Shi K, Sundaralingam M
Structure 11 825-31 (2003)
PMID: 12842045

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196115 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
5'-R(*UP*(BGM)GP*AP*GP*GP*U)-3' Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 2 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand NA 5 x NA
Ligand NCO 1 x NCO
1 modified residue:
Ligand BGM 1 x BGM

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: I422
Unit cell:
a: 35.956Å b: 35.956Å c: 38.045Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.172 0.194
Expression system: Not provided

Quick links

Citations

4 review citations

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
3 more

1 mention without citation

Non-G Base Tetrads.
Escaja et al. (2022)