› 1mdt

X-ray diffraction
2.3Å resolution

THE REFINED STRUCTURE OF MONOMERIC DIPHTHERIA TOXIN AT 2.3 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1mdt/pdb
PDB entry 1mdt coloured by chain, front view.
PDB entry 1mdt coloured by chain, side view.
PDB entry 1mdt coloured by chain, top view.
Source organism: Corynephage beta
Primary publication:
Refined structure of monomeric diphtheria toxin at 2.3 A resolution.
Bennett MJ, Eisenberg D
Protein Sci 3 1464-75 (1994)
PMID: 7833808

Function and Biology Details

Reaction catalysed: 
NAD(+) + diphthamide-[translation elongation factor 2] = nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132743 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Diphtheria toxin Chains: A, B
Molecule details ›
Chains: A, B
Length: 535 amino acids
Theoretical weight: 58.41 KDa
Source organism: Corynephage beta
Expression system: Not provided
UniProt:
  • Canonical: P00588 (Residues: 33-567; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand APU 2 x APU
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 168.5Å b: 135.5Å c: 47Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 not available
Expression system: Not provided

Quick links

Citations

25 review citations

3D domain swapping: a mechanism for oligomer assembly.
Bennett et al. (1995)
24 more

26 mentions without citation

3D domain swapping: as domains continue to swap.
Liu et al. (2002)
25 more