› 1mg4

X-ray diffraction
1.5Å resolution

STRUCTURE OF N-TERMINAL DOUBLECORTIN DOMAIN FROM DCLK: WILD TYPE PROTEIN

Released:
DOI: 10.2210/pdb1mg4/pdb
PDB entry 1mg4 coloured by chain, front view.
PDB entry 1mg4 coloured by chain, side view.
PDB entry 1mg4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The DCX-domain tandems of doublecortin and doublecortin-like kinase.
Kim MH, Cierpicki T, Derewenda U, Krowarsch D, Feng Y, Devedjiev Y, Dauter Z, Walsh CA, Otlewski J, Bushweller JH, Derewenda ZS
Nat Struct Biol 10 324-33 (2003)
PMID: 12692530

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127282 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase DCLK1 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15075 (Residues: 49-154; Coverage: 14%)
Gene names: DCAMKL1, DCDC3A, DCLK1, KIAA0369
Sequence domains: Doublecortin
Structure domains: Doublecortin domain

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 85.981Å b: 29.621Å c: 40.332Å
α: 90° β: 101.33° γ: 90°
R-values:
R R work R free
0.155 0.153 0.187
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases.
Bogoyevitch et al. (2006)
14 more

9 mentions without citation

Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis.
Carli et al. (2023)
8 more