› 1mg8

Solution NMR

NMR structure of ubiquitin-like domain in murine Parkin

Released:
DOI: 10.2210/pdb1mg8/pdb
PDB entry 1mg8 coloured by chain, ensemble of 10 models, front view.
PDB entry 1mg8 coloured by chain, ensemble of 10 models, side view.
PDB entry 1mg8 coloured by chain, ensemble of 10 models, top view.
Source organism: Mus musculus
Primary publication:
NMR structure of ubiquitin-like domain in PARKIN: gene product of familial Parkinson's disease.
Tashiro M, Okubo S, Shimotakahara S, Hatanaka H, Yasuda H, Kainosho M, Yokoyama S, Shindo H
J Biomol NMR 25 153-6 (2003)
PMID: 12652124

Function and Biology Details

Reaction catalysed: 
(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RBR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase parkin Chain: A
Molecule details ›
Chain: A
Length: 78 amino acids
Theoretical weight: 8.92 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9WVS6 (Residues: 1-76; Coverage: 16%)
Gene names: Park2, Prkn
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing

Quick links

Citations

2 review citations

RBR E3 ubiquitin ligases: new structures, new insights, new questions.
Spratt et al. (2014)
1 more

3 mentions without citation

The natural history of ubiquitin and ubiquitin-related domains.
Burroughs et al. (2012)
2 more