› 1mi1

X-ray diffraction
2.9Å resolution

Crystal Structure of the PH-BEACH Domain of Human Neurobeachin

Released:
DOI: 10.2210/pdb1mi1/pdb
PDB entry 1mi1 coloured by chain, front view.
PDB entry 1mi1 coloured by chain, side view.
PDB entry 1mi1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain.
Jogl G, Shen Y, Gebauer D, Li J, Wiegmann K, Kashkar H, Krönke M, Tong L
EMBO J 21 4785-95 (2002)
PMID: 12234919

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185536 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurobeachin Chains: A, B
Molecule details ›
Chains: A, B
Length: 414 amino acids
Theoretical weight: 48.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NFP9 (Residues: 2150-2563; Coverage: 14%)
Gene names: BCL8B, KIAA1544, LYST2, NBEA
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 16 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: P61
Unit cell:
a: 179.91Å b: 179.91Å c: 98.54Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.23 0.264
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Chediak-Higashi syndrome.
Kaplan et al. (2008)
13 more

5 mentions without citation

Multipass membrane protein structure prediction using Rosetta.
Yarov-Yarovoy et al. (2006)
4 more