› 1mii

Solution NMR

SOLUTION STRUCTURE OF ALPHA-CONOTOXIN MII

Released:
DOI: 10.2210/pdb1mii/pdb
PDB entry 1mii coloured by chain, ensemble of 20 models, front view.
PDB entry 1mii coloured by chain, ensemble of 20 models, side view.
PDB entry 1mii coloured by chain, ensemble of 20 models, top view.
Source organism: Conus magus
Primary publication:
Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity.
Hill JM, Oomen CJ, Miranda LP, Bingham JP, Alewood PF, Craik DJ
Biochemistry 37 15621-30 (1998)
PMID: 9843366

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157506 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin MII Chain: A
Molecule details ›
Chain: A
Length: 17 amino acids
Theoretical weight: 1.72 KDa
Source organism: Conus magus
Expression system: Not provided
UniProt:
  • Canonical: P56636 (Residues: 49-64; Coverage: 34%)
Sequence domains: Alpha conotoxin precursor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

8 review citations

Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes.
McIntosh et al. (1999)
7 more

11 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
10 more