› 1miq

X-ray diffraction
2.5Å resolution

Crystal structure of proplasmepsin from the human malarial pathogen Plasmodium vivax

Released:
DOI: 10.2210/pdb1miq/pdb
PDB entry 1miq coloured by chain, front view.
PDB entry 1miq coloured by chain, side view.
PDB entry 1miq coloured by chain, top view.
Source organism: Plasmodium vivax
Primary publication:
Structural insights into the activation of P. vivax plasmepsin.
Bernstein NK, Cherney MM, Yowell CA, Dame JB, James MN
J Mol Biol 329 505-24 (2003)
PMID: 12767832

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130225 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase A1 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 375 amino acids
Theoretical weight: 42.76 KDa
Source organism: Plasmodium vivax
Expression system: Escherichia coli
UniProt:
  • Canonical: O60989 (Residues: 76-450; Coverage: 83%)
Gene names: PVC01_130047600, PVT01_130045800, PVW1_130047400
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B
Spacegroup: C2
Unit cell:
a: 149.409Å b: 92.735Å c: 99.132Å
α: 90° β: 130.11° γ: 90°
R-values:
R R work R free
0.205 0.203 0.245
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Plasmepsins as potential targets for new antimalarial therapy.
Ersmark et al. (2006)
2 more

10 mentions without citation

Structural studies of vacuolar plasmepsins.
Bhaumik et al. (2012)
9 more