› 1mix

X-ray diffraction
1.75Å resolution

Crystal structure of a FERM domain of Talin

Released:
DOI: 10.2210/pdb1mix/pdb
PDB entry 1mix coloured by chain, front view.
PDB entry 1mix coloured by chain, side view.
PDB entry 1mix coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structural determinants of integrin recognition by talin.
García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC
Mol Cell 11 49-58 (2003)
PMID: 12535520

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Talin-1 Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 23.89 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54939 (Residues: 196-400; Coverage: 8%)
Gene names: TLN, TLN1
Sequence domains: FERM central domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-D
Spacegroup: C2
Unit cell:
a: 55.439Å b: 55.97Å c: 68.242Å
α: 90° β: 111.25° γ: 90°
R-values:
R R work R free
0.199 0.199 0.239
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

98 review citations

Environmental sensing through focal adhesions.
Geiger et al. (2009)
97 more

8 mentions without citation

The Structure of the talin head reveals a novel extended conformation of the FERM domain.
Elliott et al. (2010)
7 more