› 1mju

X-ray diffraction
1.22Å resolution

1.22 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6-12

Released:
DOI: 10.2210/pdb1mju/pdb
PDB entry 1mju coloured by chain, front view.
PDB entry 1mju coloured by chain, side view.
PDB entry 1mju coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity.
Ruzheinikov SN, Muranova TA, Sedelnikova SE, Partridge LJ, Blackburn GM, Murray IA, Kakinuma H, Takahashi-Ando N, Shimazaki K, Sun J, Nishi Y, Rice DW
J Mol Biol 332 423-35 (2003)
PMID: 12948492

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213050 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IMMUNOGLOBULIN MS6-12 Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.19 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
IMMUNOGLOBULIN MS6-12 Chain: H
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 24.37 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 6 x GOL
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P212121
Unit cell:
a: 56.046Å b: 65.349Å c: 138.563Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.124 0.123 0.154
Expression system: Mus musculus

Quick links

Citations

1 review citation

Antibody structure, instability, and formulation.
Wang et al. (2007)
8 other articles

6 mentions without citation

A new clustering of antibody CDR loop conformations.
North et al. (2011)
5 more