› 1mkf

X-ray diffraction
2.1Å resolution

VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS 68

Released:
DOI: 10.2210/pdb1mkf/pdb
PDB entry 1mkf coloured by chain, front view.
PDB entry 1mkf coloured by chain, side view.
PDB entry 1mkf coloured by chain, top view.
Source organism: Murid gammaherpesvirus 4
Primary publication:
Structural basis of chemokine sequestration by a herpesvirus decoy receptor.
Alexander JM, Nelson CA, van Berkel V, Lau EK, Studts JM, Brett TJ, Speck SH, Handel TM, Virgin HW, Fremont DH
Cell 111 343-56 (2002)
PMID: 12419245

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-128791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
M3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 382 amino acids
Theoretical weight: 41.83 KDa
Source organism: Murid gammaherpesvirus 4
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O41925 (Residues: 25-406; Coverage: 94%)
Gene names: GAMMAHV.M3, M3
Sequence domains: M3
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2
Unit cell:
a: 140.9Å b: 67.3Å c: 93.9Å
α: 90° β: 120.4° γ: 90°
R-values:
R R work R free
0.228 0.228 0.273
Expression system: Spodoptera frugiperda

Quick links

Citations

25 review citations

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.
Cyster JG. (2005)
24 more

9 mentions without citation

The binding and specificity of chemokine binding proteins, through the lens of experiment and computation.
Stark et al. (2022)
8 more