› 1mmj

X-ray diffraction
2.2Å resolution

Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706

Released:
DOI: 10.2210/pdb1mmj/pdb
PDB entry 1mmj coloured by chain, front view.
PDB entry 1mmj coloured by chain, side view.
PDB entry 1mmj coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor.
Kinoshita T, Nakanishi I, Sato A, Tada T
Bioorg Med Chem Lett 13 21-4 (2003)
PMID: 12467609

Function and Biology Details

Reaction catalysed: 
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133451 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chymotrypsin-like elastase family member 1 Chain: N
Molecule details ›
Chain: N
Length: 240 amino acids
Theoretical weight: 25.93 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P00772 (Residues: 27-266; Coverage: 96%)
Gene names: CELA1, ELA1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

3 bound ligands:
Ligand SO4 1 x SO4
Ligand CA 1 x CA
Ligand FR1 1 x FR1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 51.29Å b: 58.31Å c: 75.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.215 0.241

Quick links

Citations

3 citation in other articles

Binding structure of elastase inhibitor scyptolin A.
Matern et al. (2003)
2 more

1 mention without citation

Structure of the complex of porcine pancreatic elastase with a trimacrocyclic peptide inhibitor FR901451.
Kinoshita et al. (2005)