› 1mp7

Solution NMR

A Third Complex of Post-Activated Neocarzinostatin Chromophore with DNA. Bulge DNA Binding from the Minor Groove

Released:
DOI: 10.2210/pdb1mp7/pdb
PDB entry 1mp7 coloured by chain, ensemble of 9 models, front view.
PDB entry 1mp7 coloured by chain, ensemble of 9 models, side view.
PDB entry 1mp7 coloured by chain, ensemble of 9 models, top view.
Source organism: Synthetic construct
Primary publication:
New complex of post-activated neocarzinostatin chromophore with DNA: bulge DNA binding from the minor groove.
Kwon Y, Xi Z, Kappen LS, Goldberg IH, Gao X
Biochemistry 42 1186-98 (2003)
PMID: 12564921

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114197 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*GP*CP*CP*AP*GP*AP*GP*AP*GP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 10 nucleotides
Theoretical weight: 3.08 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NCG 1 x NCG
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing, restrained molecular dynamics
Expression system: Not provided

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Citations

8 citation in other articles

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
Liu et al. (2005)
7 more

4 mentions without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
3 more