› 1mqa

X-ray diffraction
2.5Å resolution

Crystal structure of high affinity alphaL I domain in the absence of ligand or metal

Released:
DOI: 10.2210/pdb1mqa/pdb
PDB entry 1mqa coloured by chain, front view.
PDB entry 1mqa coloured by chain, side view.
PDB entry 1mqa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.
Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA
Cell 112 99-111 (2003)
PMID: 12526797

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149031 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-L Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 20.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P20701 (Residues: 153-331; Coverage: 16%)
Gene names: CD11A, ITGAL
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 61.864Å b: 121.324Å c: 54.059Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.28 0.249 0.283
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

99 review citations

Structural basis of integrin regulation and signaling.
Luo et al. (2007)
98 more

6 mentions without citation

Microneme proteins in apicomplexans.
Carruthers et al. (2008)
5 more