› 1mqz

Solution NMR

NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles

Released:
DOI: 10.2210/pdb1mqz/pdb
PDB entry 1mqz coloured by chain, ensemble of 17 models, front view.
PDB entry 1mqz coloured by chain, ensemble of 17 models, side view.
PDB entry 1mqz coloured by chain, ensemble of 17 models, top view.
Source organism: Bacillus sp. HIL-Y85/54728
Primary publication:
NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity.
Hsu ST, Breukink E, Bierbaum G, Sahl HG, de Kruijff B, Kaptein R, van Nuland NA, Bonvin AM
J Biol Chem 278 13110-7 (2003)
PMID: 12562773

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155121 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lantibiotic mersacidin Chain: A
Molecule details ›
Chain: A
Length: 20 amino acids
Theoretical weight: 1.83 KDa
Source organism: Bacillus sp. HIL-Y85/54728
UniProt:
  • Canonical: P43683 (Residues: 49-67; Coverage: 28%)
Gene name: mrsA

Ligands and Environments

No bound ligands
2 modified residues:
Ligand DBB 4 x DBB
Ligand DHA 1 x DHA

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING TORSION, ANGLE DYNAMICS

Quick links

Citations

24 review citations

Lantibiotics: peptides of diverse structure and function.
Willey et al. (2007)
23 more

2 mentions without citation

The role of hydrophobic interactions in positioning of peripheral proteins in membranes.
Lomize et al. (2007)
1 more