› 1mr0

Solution NMR

SOLUTION NMR STRUCTURE OF AGRP(87-120; C105A)

Released:
DOI: 10.2210/pdb1mr0/pdb
PDB entry 1mr0 coloured by chain, ensemble of 40 models, front view.
PDB entry 1mr0 coloured by chain, ensemble of 40 models, side view.
PDB entry 1mr0 coloured by chain, ensemble of 40 models, top view.
Source organism: Homo sapiens
Primary publication:
Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity.
Jackson PJ, McNulty JC, Yang YK, Thompson DA, Chai B, Gantz I, Barsh GS, Millhauser GL
Biochemistry 41 7565-72 (2002)
PMID: 12056887

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126197 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Agouti-related protein Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O00253 (Residues: 87-120; Coverage: 30%)
Gene names: AGRP, AGRT, ART
Sequence domains: Agouti protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

12 review citations

Alternative binding proteins: biological activity and therapeutic potential of cystine-knot miniproteins.
Kolmar H. (2008)
11 more

2 mentions without citation

Engineering agatoxin, a cystine-knot peptide from spider venom, as a molecular probe for in vivo tumor imaging.
Moore et al. (2013)
1 more