› 1mtq

Solution NMR

THREE-DIMENSIONAL SOLUTION STRUCTURE OF ALPHA-CONOTOXIN GID BY NMR SPECTROSCOPY

Released:
DOI: 10.2210/pdb1mtq/pdb
PDB entry 1mtq coloured by chain, ensemble of 20 models, front view.
PDB entry 1mtq coloured by chain, ensemble of 20 models, side view.
PDB entry 1mtq coloured by chain, ensemble of 20 models, top view.
Source organism: synthetic construct
Primary publication:
Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence.
Nicke A, Loughnan ML, Millard EL, Alewood PF, Adams DJ, Daly NL, Craik DJ, Lewis RJ
J Biol Chem 278 3137-44 (2003)
PMID: 12419800

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157989 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin GID Chain: A
Molecule details ›
Chain: A
Length: 19 amino acids
Theoretical weight: 2.19 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P60274 (Residues: 45-63; Coverage: 42%)
Sequence domains: Alpha conotoxin precursor

Ligands and Environments

No bound ligands
2 modified residues:
Ligand CGU 1 x CGU
Ligand HYP 1 x HYP

Experiments and Validation Details

Entry percentile scores
Refinement method: Initial structures were calculated using torsion angle dynamics and structures were refined in a water shell using cartesian dynamics.
Expression system: Not provided

Quick links

Citations

26 review citations

Therapeutic potential of venom peptides.
Lewis et al. (2003)
25 more

8 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
7 more