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Solution NMR

NMR solution structure of a Bowman Birk inhibitor isolated from snail medic seeds (Medicago Scutellata)

Released:
DOI: 10.2210/pdb1mvz/pdb
PDB entry 1mvz coloured by chain, ensemble of 15 models, front view.
PDB entry 1mvz coloured by chain, ensemble of 15 models, side view.
PDB entry 1mvz coloured by chain, ensemble of 15 models, top view.
Source organism: Medicago scutellata
Primary publication:
Anticarcinogenic Bowman Birk inhibitor isolated from snail medic seeds (Medicago scutellata): solution structure and analysis of self-association behavior.
Catalano M, Ragona L, Molinari H, Tava A, Zetta L
Biochemistry 42 2836-46 (2003)
PMID: 12627949

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160389 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bowman-Birk type proteinase inhibitor Chain: A
Molecule details ›
Chain: A
Length: 62 amino acids
Theoretical weight: 6.94 KDa
Source organism: Medicago scutellata
UniProt:
  • Canonical: P80321 (Residues: 1-62; Coverage: 100%)
Sequence domains: Bowman-Birk serine protease inhibitor family
Structure domains: Cysteine Protease (Bromelain) Inhibitor, subunit H

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing torsion angle dynamics energy minimization

Quick links

Citations

3 review citations

Structural features and molecular evolution of Bowman-Birk protease inhibitors and their potential application.
Qi et al. (2005)
2 more

2 mentions without citation

Plant Protease Inhibitors in Therapeutics-Focus on Cancer Therapy.
Srikanth et al. (2016)
1 more