› 1n14

Solution NMR

Structure and Dynamics of Thioguanine-modified Duplex DNA in Comparison with Unmodified DNA; Structure of Unmodified Duplex DNA

Released:
DOI: 10.2210/pdb1n14/pdb
PDB entry 1n14 coloured by chain, ensemble of 20 models, front view.
PDB entry 1n14 coloured by chain, ensemble of 20 models, side view.
PDB entry 1n14 coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
Structure and dynamics of thioguanine-modified duplex DNA.
Somerville L, Krynetski EY, Krynetskaia NF, Beger RD, Zhang W, Marhefka CA, Evans WE, Kriwacki RW
J Biol Chem 278 1005-11 (2003)
PMID: 12401802

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114216 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*GP*CP*TP*AP*AP*GP*GP*AP*AP*AP*GP*CP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 13 nucleotides
Theoretical weight: 4.01 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*GP*GP*CP*TP*TP*TP*CP*CP*TP*TP*AP*GP*C)-3' Chain: B
Molecule details ›
Chain: B
Length: 13 nucleotides
Theoretical weight: 3.93 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: restrained molecular dynamics, relaxation matrix analysis
Expression system: Not provided

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Citations

15 review citations

Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing.
Teml et al. (2007)
14 more