› 1n1i

X-ray diffraction
2.4Å resolution

The structure of MSP-1(19) from Plasmodium knowlesi

Released:
DOI: 10.2210/pdb1n1i/pdb
PDB entry 1n1i coloured by chain, front view.
PDB entry 1n1i coloured by chain, side view.
PDB entry 1n1i coloured by chain, top view.
Source organism: Plasmodium knowlesi strain H
Primary publication:
Structure of the C-terminal domains of merozoite surface protein-1 from Plasmodium knowlesi reveals a novel histidine binding site.
Garman SC, Simcoke WN, Stowers AW, Garboczi DN
J Biol Chem 278 7264-9 (2003)
PMID: 12493733

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190421 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Merozoite surface protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 105 amino acids
Theoretical weight: 11.45 KDa
Source organism: Plasmodium knowlesi strain H
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9GSQ9 (Residues: 232-328; Coverage: 30%)
Gene name: MSP1
Sequence domains: MSP1 EGF domain 1
Structure domains: Laminin

Ligands and Environments

2 bound ligands:
Ligand IMD 2 x IMD
Ligand HIS 1 x HIS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 33.88Å b: 106.46Å c: 62.69Å
α: 90° β: 102.05° γ: 90°
R-values:
R R work R free
0.234 0.234 0.264
Expression system: Saccharomyces cerevisiae

Quick links

Citations

3 review citations

The carboxy-terminus of merozoite surface protein 1: structure, specific antibodies and immunity to malaria.
Holder AA. (2009)
2 more

3 mentions without citation

Chemical Biology Tools To Investigate Malaria Parasites.
Broichhagen et al. (2021)
2 more